ADAM10

ADAM10
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1M1I
Dynodwyr
Cyfenwau	ADAM10, AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz, CDw156, ADAM metallopeptidase domain 10
Dynodwyr allanol	OMIM: 602192 HomoloGene: 865 GeneCards: ADAM10
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • SH3 domain binding; • endopeptidase activity; • metal ion binding; • integrin binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • signaling receptor binding; • hydrolase activity; • protein kinase binding; • metallopeptidase activity; • metalloendopeptidase activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • GO:0097483, GO:0097481 postsynaptic density; • focal adhesion; • Cellbilen; • perinuclear endoplasmic reticulum; • Golgi-associated vesicle; • tetraspanin-enriched microdomain; • extracellular exosome; • cnewyllyn cell; • cell surface; • Golgi membrane; • extracellular space; • Golgi apparatus; • specific granule membrane; • tertiary granule membrane; • endoplasmic reticulum lumen; • trans-Golgi network; • synaptic vesicle; • dendrite; • neuronal cell body; • dendritic spine; • postsynaptic membrane; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• Notch signaling pathway; • positive regulation of cell migration; • ephrin receptor signaling pathway; • cell-cell signaling; • constitutive protein ectodomain proteolysis; • protein processing; • extracellular matrix disassembly; • in utero embryonic development; • proteolysis; • monocyte activation; • response to tumor necrosis factor; • protein phosphorylation; • positive regulation of cell growth; • positive regulation of T cell chemotaxis; • positive regulation of cell population proliferation; • Notch receptor processing; • integrin-mediated signaling pathway; • membrane protein ectodomain proteolysis; • negative regulation of cell adhesion; • neutrophil degranulation; • post-translational protein modification; • spermatogenesis; • amyloid-beta formation; • Notch receptor processing, ligand-dependent; • positive regulation of apoptotic process; • regulation of dendritic spine morphogenesis; • response to antineoplastic agent; • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; • postsynapse organization;
	Sources:Amigo / QuickGO
Orthologau
	102
	n/a
	ENSG00000137845
	n/a
	O14672
	n/a
	NM_001110; NM_001320570
	n/a
	NP_001101; NP_001307499; NP_001101.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAM10 yw ADAM10 a elwir hefyd yn Disintegrin and metalloproteinase domain-containing protein 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q21.3.^[2]

[1] "Human PubMed Reference:".

[2] ADAM10 - Cronfa NCBI

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